A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing

Nature, Published online: 08 July 2020; doi:10.1038/s41586-020-2477-4

An interbacterial toxin that catalyses the deamination of cytidines within double-stranded DNA forms part of a CRISPR-free, RNA-free base editing system that enables manipulation of human mitochondrial DNA.

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